Focused Ultrasound Surgery in Oncology | HIFU

Focused Ultrasound surgery in Oncology, HIFU o FUS, is a non-invasive oncological procedure to treat tumors without use of radiation, X-Ray.
Ultrasound Therapy HIFU stands for High Intensity Focused Ultrasound, system to treat cancers pathologies and/ or to improve the quality of life of patients. Compatible with other therapies and may be a viable alternative to traditional surgery.
Despite the great advances made in the field of preventive and therapeutic, cancer remains the second leading cause of death in developed countries and is among the top three leading causes of death in developing countries. In 2000 alone there were 10 million new cases of cancer worldwide, and more than 6 million people have died because of cancer. Always 2000 data indicate that 22 million people were affected by cancer.
In addition to drug treatment, there are several tools and methods available to fight cancer: surgery, radiation therapy, chemotherapy, brachytherapy, hyperthermia, etc.
Among the most advanced technologies in Oncology Interventional, we find the HIFU system. Technology that has proved useful to attack the pathology without recourse to surgery, based on the use of high-intensity ultrasound that through the thermo-ablation treats the tumor.
How does it work? This technology; medical procedure uses High Intensity Focused Ultrasound for ablation and tissue destruction pathogens quickly in a given area (Focal Area). It is one of the latest methods used to treat Tumors and one of the ways of ultrasonography however the HIFU technology induced hyperthermia.
The treatment with the HIFU technology is not radioactive or toxic. More focused therapy that could change the lives of those who must undergo the heavy cycles of treatment to fight benign and/or malignant tumors. A technology that has existed for about 20 years but, thanks to new research in the field, and has finally been set up to bring real benefits to patients.

Ablation and therapeutic procedures

In medicine the term ablation indicates the creation of a necrosis of a portion of biological tissue. The techniques of thermal ablation are therapeutic procedures that aim to destroy diseased tissue (typically cancers) by a thermal heating without damaging adjacent structures vital. The cells that make up the tissue, in fact, cannot withstand high temperatures and suffer damage in different amounts according to the temperature range of which they are subjected. To understand how heat interacts with biological tissue, you can define some variables, values, temperature associate cellular damage:

40 °C	Slight increase in temperature causes the cellular homeostasis
40 °C- 45°C	Value of hyperthermia moderate
46 °C	Cells begin to suffer irreversible damage but with slow speed
50 °C - 52 ° C	Cells undergo irreversible damage with a reduced speed
60 °C - 100°C	Coagulation necrosis, irreversible cell damage involving the main cytosolic enzymes, mitochondrial complexes and histone-nucleic acids and thermal damage also occurs in the course of a few days.
105°C and over	Vaporization of the cells and subsequent carbonization.

Key objective of all ablative therapies is therefore to achieve and maintain a temperature between 60 °C and 100 °C throughout the volume of the tissue to be treated to induce coagulative necrosis.
Treat and hit only the tumor tissue is not trivial since the separation between healthy tissue and sick is not clear and so he agrees to include in the therapy a margin of 0.5-1 cm, apparently healthy tissue that may contain microscopic metastatic of tumors.
The Termo Ablative techniques can be used by many sources of energy to provide heating necessary and to induce coagulative necrosis.
The following are the main source of heating cytotoxic energy:
# Electromagnetic Energy - both in the form of radio frequency waves RFA or Microwaves
# Acoustic Energy - through the use of focused ultrasound high power High-Intensity Focused Ultrasound, HIFU.
# Laser Energy - photocoagulation.
# Heated drugs – anti cancer drugs administered during hyperthermia. Usually used in injection techniques.

Ablation with HIFU Technology | Advanced Therapy in Surgical Oncology

One of the advanced therapy in surgical Oncology by ablation is based on the principle of the method HIFU, generator of high-frequency sound waves, ultrasound.
The frequency is above 20,000 cycles per second, or 20 kilohertz. The high power of the focused sound waves is used to induce necrosis in a Focal Area, the target point.



HIFU | main composition of the system
# Transducer
Ultrasounds are generated through ultrasonic transducer.
A transducer is a device that converts a signal in a form of energy to a signal in another form of energy.
# Beam
The first problem that is created with the ultrasound imaging is due to the ultrasonic beam. It, in fact, is very different from what can be a light beam which is typically collimated (that constituted by plane waves traveling in a straight line).
An ultrasonic beam is much more complex and can be decomposed into three parts: Side lobes, Zone of Fresnel, Zone of Fraunhofer.
# Focusing System - Imaging
The HIFU systems can be classified according to the technique of imaging used. There are currently two types of imaging: USg-HIFU (ultrasound guided HIFU) and MRg-HIFU (MRI guided HIFU).

HIFU New Generation ADF-IMS Multidisciplinary

The latest technological developments have produced a new system, a new device:
the HIFU New Generation Multidisciplinary ADF-IMS, wide range of applications. Suited to treatment of various tumors, multidisciplinary treatments. Treat many types of cancer, benign and/or malignant tumors, which are located in the following organs: prostate, bladder, kidney, liver, pancreas, stomach, uterus, (uterine myomas and uterine fibroids), urethra, breast, a part of gastrointestinal system, digestive system and more.

HIFU ADF-IMS for hospitals and clinics leading

The treatments take place in the outpatient, no anesthesia needs because of the energy flow, energy density, the tissues in the transmission path of the ultrasound is significantly reduced while maintaining a high power focal area. This uniqueness technology allows to create ablation and coagulation necrosis only in the Isocenter tissue cells safeguarding surrounding areas (different from all others systems with a static energy flow).
Some others features:
# Saving surrounding tissues
# Dynamic energy flow
# No anesthesia needs
# No side effects
# No radioactive
# Outpatient treatment
# Compatible with other therapies
# Real time management and control
# Optimal asset
# Management Savings, Excellent Workflow
# No heavy structural shields needs
# Particular design for a compact space
# High performance factors



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AGADA' medical technologies | HIFU ADF- IMS New Generation multidisciplinary
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